新型MR特异性对比剂Gd-聚氰基丙烯酸正丁酯纳米微粒的合成及其肝脏靶向性作用.pdfVIP

中国组织工程研究与临床康复第12 在第I 那 2008 - 01 - 01 出版 Journal ofClinical Rehabilitative 1ìssue Engineering R.臼earch Januaη， 1， 2008 Vol.12, NO.I @定死定基础实验 新型MR特异性对比剂Gd-聚氨基丙烯酸正丁醋纳米微粒的合成及其 肝脏靶向性作用合 吕国士1 ，许乙凯2 羹篓旨在噜It!ii掰协勾销脑笛..结粤届组黯-鸡撞国...踊 一 ，喔掏醺苟每密法组幢霉擎踊通~割蜀翻.跑黯擎i!;..1毒后吃笨艳、，制鄂、是ß_-;$ 甲唱揭揭·白酶蹦蹦-恒鲁酶萄胁每建揭...甜跚自..回邸湿蛐姐回萨- Gd-polybutylcyanoacrylate nanoparticle as a novel MR specific contrast agent: Synthesis and target for the liver 1 2 Lu Guo-shi , Xu Yi-kai Abstract AIM: It is selecting MRI targeted contrast agent accumulated on certain tissues or organs that contributes to increase the accuracy lCent町 of Imaging, the and sensitivity of MRI diagnosis. This study prepared polybutylcyanoacrylate nanoparticles (PBCA-NP) loaded with Gd-DTPA as 251 Hα翻pl国1 of Chi- n臼e PLA, Zl回n!IJ国­ targeted contrast agents , investigated the enhancement for the liver in animal experiment , and debated the potential value of its kou 075创阳， Hebei application. Province , α由四 METHODS: The experiment was finished in the Imaging Center of Nanfang Hospital between September 2004 and January Cen恼。f 1n回gíng， 2005 ( Gd-PBCA-NP were prepared by anionic emulsion polymerization. ( The size and distribution of Gd-PBCA-NP were Nar由ngHospi园。t measured by Malvem-3000HS laser analyzer ③High-台equency inductively ∞upled plasma-atomic emission spectrometry was Sou曲目n M，封回l Universi凯Guar鸣曲u