dynamic probing of nanoparticle stability in vivo a liposomal model assessed using in situ microdialysis and optical imaging纳米颗粒稳定的动态探测体内脂质体模型评估使用和原位微量透析可把时程延长光学成像.pdfVIP

Hindawi Publishing Corporation Journal of Nanomaterials Volume 2011, Article ID 932719, 8 pages doi:10.1155/2011/932719 Research Article Dynamic Probing of Nanoparticle Stability In Vivo: A Liposomal Model Assessed Using In Situ Microdialysis and Optical Imaging Chien-Chung Jeng,1, 2 Shih-Hsun Cheng,2, 3 Ja-an Annie Ho,4 Sam Hong-Yi Huang,2 Jerry C. Chang,2 Pi-Ju Tsai,5 Chung-Shi Yang,5 and Leu-Wei Lo2 1 Department of Physics, National Chung Hsing University, Taichung 420, Taiwan 2 Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Miaoli 350, Taiwan 3 Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu 300, Taiwan 4 Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan 5 Center for Nanomedicine Research, National Health Research Institutes, Zhunan, Miaoli 350, Taiwan Correspondence should be addressed to Leu-Wei Lo, lwlo@.tw Received 7 June 2010; Revised 10 August 2010; Accepted 6 September 2010 Academic Editor: Libo Wu Copyright © 2011 Chien-Chung Jeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Nanoparticle-mediated drug delivery and controlled release has been a vigorous research area in contemporary nanomedicine. The in vivo stability of nanoparticle delivered on site is a prerequisite for the design of drug-controlled release by any means. In this study, the first methodology comprised of microdialysis and optical imaging to assess the liposome stability in vivo is reported. Macroscopically, we demonstrated the DPPG liposomes with negative surface charge fast accumulated in the rat liv