friend turns foe transformation of anti-inflammatory hdl to proinflammatory hdl during acute-phase response朋友变成敌人转变促炎的抗炎高密度脂蛋白hdl在急性期反应.pdfVIP

Hindawi Publishing Corporation Cholesterol Volume 2011, Article ID 274629, 7 pages doi:10.1155/2011/274629 Review Article Friend Turns Foe: Transformation of Anti-Inflammatory HDL to Proinflammatory HDL during Acute-Phase Response Hima Bindu G,1 Veena S. Rao,1, 2 and Vijay V. Kakkar3 1 Tata Proteomics and Coagulation Unit, Thrombosis Research Institute, Bangalore, India 2 Narayana Hrudayalaya Hospital, Bangalore, India 3 Thrombosis Research Institute, London, UK Correspondence should be addressed to Veena S. Rao, veenasrao@.in Received 31 August 2010; Accepted 1 November 2010 Academic Editor: Jeffrey Cohn Copyright © 2011 Hima Bindu G et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. Introduction density, plasma HDL are divided into HDL2 (larger and less dense) and HDL3 (smaller and denser), while agarose gel High-density lipoprotein (HDL) is a plasma lipoprotein electrophoresis further discriminates the basic HDL fraction heterogeneous in origin, size, composition, and function. It (α-lipoproteins) and a small fraction, pre-β -HDL. is a major carrier of cholesterol in blood, and unlike other Plasma HDL are spherical or discoidal particles of highly lipoproteins, physiological functions of HDL influence the hydrated density (1.063–1.21 g/mL) due to elevated protein cardiovascular system favorably unless it is modified patho- content [4]. Discoidal HDL are small lipid-poor nascent logically. The atheroprotective role of HDL is attributed to