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basal cell carcinoma in type 2 segmental dariers disease基底细胞癌2型节段性毛囊角化病
Hindawi Publishing Corporation
Journal of Skin Cancer
Volume 2012, Article ID 839561, 4 pages
doi:10.1155/2012/839561
Case Report
Basal Cell Carcinoma in Type 2 Segmental Darier’s Disease
Lynne Robertson1 and Maxwell B. Sauder2
1 Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, Canada
2 Division of Dermatology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
Correspondence should be addressed to Maxwell B. Sauder, maxwell.sauder@medportal.ca
Received 11 March 2011; Revised 17 May 2011; Accepted 17 May 2011
Academic Editor: Daniela Massi
Copyright © 2012 L. Robertson and M. B. Sauder. This is an open access article distributed under the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is
properly cited.
Background. Darier’s disease (DD), also known as Keratosis Follicularis or Darier-White disease, is a rare disorder of keratinization.
´
DD can present as a generalized autosomal dominant condition as well as a localized or segmental postzygotic condition (Vazquez
et al., 2002). Clinical features of DD include greasy, warty papules and plaques on seborrheic areas, dystrophic nails, palmo-plantar
pits, and papules on the dorsum of the hands and feet. Objective. We report a case of basal cell carcinoma developing in a patient
with type 2 segmental DD. Conclusion. According to the current literature, Type 2 segmental disease is a rare presentation of
Darier’s disease with only 8 previous cases reported to date. In addition, nonmelanoma skin cancer (NMSC) arising from DD is
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