fabrication and characterization of collagen-immobilized porous phbvha nanocomposite scaffolds for bone tissue engineering制备和表征collagen-immobilized多孔phbvha纳米复合材料为骨组织工程支架.pdfVIP

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fabrication and characterization of collagen-immobilized porous phbvha nanocomposite scaffolds for bone tissue engineering制备和表征collagen-immobilized多孔phbvha纳米复合材料为骨组织工程支架.pdf

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fabrication and characterization of collagen-immobilized porous phbvha nanocomposite scaffolds for bone tissue engineering制备和表征collagen-immobilized多孔phbvha纳米复合材料为骨组织工程支架

Hindawi Publishing Corporation Journal of Nanomaterials Volume 2012, Article ID 171804, 11 pages doi:10.1155/2012/171804 Research Article Fabrication and Characterization of Collagen-Immobilized Porous PHBV/HA Nanocomposite Scaffolds for Bone Tissue Engineering Jin-Young Baek, Zhi-Cai Xing, Giseop Kwak, Keun-Byoung Yoon, Soo-Young Park, Lee Soon Park, and Inn-Kyu Kang Department of Polymer Science and Engineering, Kyungpook National University, Daegu 702-701, Republic of Korea Correspondence should be addressed to Inn-Kyu Kang, ikkang@knu.ac.kr Received 6 December 2011; Revised 3 February 2012; Accepted 6 February 2012 Academic Editor: Zhongkui Hong Copyright © 2012 Jin-Young Baek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The porous composite scaﬀolds (PHBV/HA) consisting of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and hydroxyapatite (HA) were fabricated using a hot-press machine and salt-leaching. Collagen (type I) was then immobilized on the surface of the porous PHBV/HA composite scaﬀolds to improve tissue compatibility. The structure and morphology of the collagen-immobilized composite scaﬀolds (PHBV/HA/Col) were investigated using a scanning electron microscope (SEM), Fourier transform infrared (FTIR), and electron spectroscopy for chemical analysis (ESCA). The potential of the porous PHBV/HA/Col composite scaﬀolds for use as a bone scaﬀold was assessed by an experiment with osteoblast cells (MC3T3-E1) in terms of cell adhesion, proliferation, and diﬀerentiation. The results showed that the PHBV/HA/Col composit