disruption of the ecm33 gene in candida albicans prevents biofilm formation, engineered human oral mucosa tissue damage and gingival cell necrosisapoptosis中断ecm33基因的白色念珠菌阻止生物膜的形成,改造人类口腔黏膜组织损伤和牙龈细胞necrosisapoptosis.pdfVIP

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disruption of the ecm33 gene in candida albicans prevents biofilm formation, engineered human oral mucosa tissue damage and gingival cell necrosisapoptosis中断ecm33基因的白色念珠菌阻止生物膜的形成,改造人类口腔黏膜组织损伤和牙龈细胞necrosisapoptosis.pdf

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disruption of the ecm33 gene in candida albicans prevents biofilm formation, engineered human oral mucosa tissue damage and gingival cell necrosisapoptosis中断ecm33基因的白色念珠菌阻止生物膜的形成,改造人类口腔黏膜组织损伤和牙龈细胞necrosisapoptosis

Hindawi Publishing Corporation Mediators of Inﬂammation Volume 2012, Article ID 398207, 9 pages doi:10.1155/2012/398207 Research Article Disruption of the ECM33 Gene in Candida albicans Prevents Bioﬁlm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis Mahmoud Rouabhia,1 Abdelhabib Semlali,2 Jyotsna Chandra,2 Pranab Mukherjee,2 Witold Chmielewski,1 and Mahmoud A. Ghannoum2 1 ´ Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval Pavillon de Medecine Dentaire, ´ ´ ´ ´ 2420 Rue de la Terrasse, QC, Canada G1V 0A6 2 Center for Medical Mycology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, USA Correspondence should be addressed to Mahmoud Rouabhia, mahmoud.rouabhia@fmd.ulaval.ca Received 13 December 2011; Revised 3 March 2012; Accepted 8 March 2012 Academic Editor: Teresa Zelante Copyright © 2012 Mahmoud Rouabhia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In this study we demonstrated that ΔCaecm33 double mutant showed reduced bioﬁlm formation and causes less damage to gingival mucosa tissues. This was conﬁrmed by the reduced level of necrotic cells and Bax/Bcl2 gene expression as apoptotic markers. In contrast, parental and Caecm33 mutant strains decreased basement membrane protein production (laminin 5 and type IV collagen). We thus propose that ECM33 gene/pr