gallic acid-loaded cellulose acetate electrospun nanofibers thermal properties, mechanical properties, and drug release behavior高卢acid-loaded醋酸纤维素静电纺丝热性能,机械性能,和药物释放行为.pdfVIP

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gallic acid-loaded cellulose acetate electrospun nanofibers thermal properties, mechanical properties, and drug release behavior高卢acid-loaded醋酸纤维素静电纺丝热性能,机械性能,和药物释放行为.pdf

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gallic acid-loaded cellulose acetate electrospun nanofibers thermal properties, mechanical properties, and drug release behavior高卢acid-loaded醋酸纤维素静电纺丝热性能,机械性能,和药物释放行为

Open Journal of Polymer Chemistry, 2012, 2, 21-29 /10.4236/ojpchem.2012.21004 Published Online February 2012 (http://www.SciRP.org/journal/ojpchem) Gallic Acid-loaded Cellulose Acetate Electrospun Nanofibers: Thermal Properties, Mechanical Properties, and Drug Release Behavior Manisara Phiriyawirut1*, Thawatchai Phaechamud2 1Department of Tool and Materials Engineering, Faculty of Engineering, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand * Email: manisara.pee@kmutt.ac.th Received December 28, 2011; revised January 28, 2012; accepted February 7, 2012 ABSTRACT The gallic acid-loaded electrospun cellulose acetate fibers were successfully prepared. The fiber containing 2.5% gallic acid was smooth surface but observed drug flake on the surface of the fiber when increasing drug content. The thermal properties, mechanical properties and drug release behavior of the fibers were investigated comparing to the corre- sponding films. Keywords: Electrospinning; Gallic Acid; Cellulose Acetate; Melting; Drug Release 1. Introduction alization, etc. [4,5]. These unique properties have trigge- red a broad range of potential applications, including Polymer fibers are used in a wide variety of applications nanocomposites [6], scaffolds for tissue engineering [7], ranging from t