coordinated increased expression of cyclooxygenase2 and nuclear factor b is a steady feature of urinary bladder carcinogenesis协调的表达增加cyclooxygenase2和核因子b是一个膀胱致癌作用的稳定特性.pdfVIP

Hindawi Publishing Corporation Advances in Urology Volume 2010, Article ID 871356, 8 pages doi:10.1155/2010/871356 Research Article Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor κB Is a Steady Feature of Urinary Bladder Carcinogenesis Stylianos Kontos,1, 2 Georgia Sotiropoulou-Bonikou,3 Athina Kominea,4 Maria Melachrinou,1 Eleni Balampani,5 and Dionysis Bonikos1 1 Department of Pathology, Medical School, University of Patras, 26504 Rion, Greece 2 Department of Urology, General Hospital of Nikaia, 18543 Peiraeus, Greece 3 Department of Anatomy and Histology-Embryology, Medical School, University of Patras, 26504 Rion, Greece 4 Department of Pathology, Aegion General Hospital, 25100 Aegion, Greece 5 Department of Microbiology, General Hospital of Nikaia, 18543 Peiraeus, Greece Correspondence should be addressed to Stylianos Kontos, kontostylianos@ Received 7 June 2010; Accepted 15 July 2010 Academic Editor: Douglas S. Scherr Copyright © 2010 Stylianos Kontos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives. The inescapable relationship between chronic inflammation and carcinogenesis has long been established. Our objective was to investigate COX-2 and NF-κB immunohistochemical expression in a large series of normal epithelium and bladder carcinomas. Methods. Immunohistochemical methodology was performed on formalin-fixed, paraffin-embedded sections from urinary bladder carcinomas of 140 patients (94 males and 46 females with bladder carcinomas). Results. COX-2 expression is increased in the cytoplas