expression of selected integrins and selectins in bullous pemphigoid选择的整合蛋白的表达和selectins大疱的类天疱疮.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2007, Article ID 31051, 7 pages doi:10.1155/2007/31051 Research Article Expression of Selected Integrins and Selectins in Bullous Pemphigoid 1 1 2 ˙ Agnieszka Zebrowska, Anna Sysa-Je¸drzejowska, Małgorzata Wa¸growska-Danilewicz, 1 3 ˙ 3 Ewa Joss-Wichman, Anna Erkiert-Polguj, and Elzbieta Waszczykowska 1 Department of Dermatology and Venereology, Medical University of Lodz, 94-017 Lodz, Poland 2 Laboratory of Nephropathology, Medical University of Lodz, 94-017 Lodz, Poland 3 Laboratory of Immunodermatology, Department of Dermatology and Venereology, Medical University of Lodz, 94-017 Lodz, Poland Received 30 November 2006; Revised 23 January 2007; Accepted 6 February 2007 Blister development in bullous pemphigoid (BP) results from destruction of hemidesmosomes and basement membrane compo- nents within the dermoepidermal junction by autoantibodies. Adhesion molecules can take part in pathogenesis of this disease. The aim of the study was to determine the localization and expression of L- and E-selectins and β 1, β3, and β4 integrins by im- munohistochemistry in skin lesions of 21 patients with BP, compared with 10 healthy subjects. Expression of L and E selectins and β 1, β3 integrins was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis, expression of β4 integrin was irregular and was detected mainly in dermal part of the blister, while in the control group only weak and single expression of the examined molecules was detecte