assessing effects of hiv heterogeneity and macrophage on the hiv pathogenesis in hiv-infected individuals评估影响艾滋病的异质性和巨噬细胞在感染艾滋病毒艾滋病发病机理的个人.pdfVIP

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assessing effects of hiv heterogeneity and macrophage on the hiv pathogenesis in hiv-infected individuals评估影响艾滋病的异质性和巨噬细胞在感染艾滋病毒艾滋病发病机理的个人.pdf

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assessing effects of hiv heterogeneity and macrophage on the hiv pathogenesis in hiv-infected individuals评估影响艾滋病的异质性和巨噬细胞在感染艾滋病毒艾滋病发病机理的个人

Journnl of Thenrdcnl Medicine, Vol. 2. pp. 245-265 @ 2000 OPA (Overseas Publ~shersAbsoc~at~on)N.V. Reprints available dlrectly from the publisher Published by license under Photocopying permitted by l~censeonly the Gordon and Breach Sc~ence Publibhers Imprint. Printed in Malays~a. Assessing Effects of HIV Heterogeneity and Macrophage on the HIV Pathogenesis in HIV-Infected Individuals WAI-YUAN TAN* and ZHENGZHENG YE Department of Mathematical Sciences, The Universi? of Meemphis, Memphis, TN 38152 (Received 22 November 1998; Injinalform 9 August 1999) Taking into account the real world situations, in this paper we have developed a stochastic model of HIV pathogenesis in HIV-infected individuals under very general conditions. In this model, we have considered five different types of CD4(+)T cells, two different types of HIV (M-tropic versus T-tropic) as well as infected and un-infected macrophage. This is a 9-dimensional stochastic process. For this process, we have developed stochastic differential equations for different types of cells. By using these stochastic equations, we have generated some