assessing errors inherent in oct-derived macular thickness maps评估固有的错误oct-derived黄斑厚度地图.pdfVIP

Hindawi Publishing Corporation Journal of Ophthalmology Volume 2011, Article ID 692574, 9 pages doi:10.1155/2011/692574 Research Article Assessing Errors Inherent in OCT-Derived Macular Thickness Maps Daniel Odell,1 Adam M. Dubis,2 Jackson F. Lever,3 Kimberly E. Stepien,1 and Joseph Carroll1, 2, 4 1 Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, USA 2 Department of Cell Biology, Neurobiology, Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA 3 Department of Ophthalmology, William Beaumont Hospital, Royal Oak, MI 48073, USA 4 Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA Correspondence should be addressed to Joseph Carroll, jcarroll@ Received 27 January 2011; Accepted 24 June 2011 Academic Editor: Eduardo Buchele Rodrigues Copyright © 2011 Daniel Odell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness maps. Forty-three patients with various retinal pathologies and 113 normal subjects were imaged using Cirrus HD-OCT. Reduced B-scan density was associated with increased interpolation error in ETDRS macular thickness plots. Correcting for individual differences in axial length revealed modest errors in retinal thickness maps, while more pronounced errors were observed when the ETDRS plot