assessment of acute and chronic pharmacological effects on energy expenditure and macronutrient oxidation in humans responses to ephedrine评估急性和慢性的药理作用对人类的能量消耗和常量营养元素氧化对麻黄素的反应.pdfVIP

Hindawi Publishing Corporation Journal of Obesity Volume 2011, Article ID 210484, 8 pages doi:10.1155/2011/210484 Research Article Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine Antonella Napolitano,1 Peter R. Murgatroyd,2 Nick Finer,2 Elizabeth K. Hussey,3 Robert Dobbins,3 Steve O’Rahilly,2 and Derek J. R. Nunez3 1 Clinical Unit in Cambridge, GlaxoSmithKline, ACCI, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ, UK 2 Wellcome Trust Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 2QQ, UK 3 Metabolic Pathways Center of Excellence for Drug Discovery, GlaxoSmithKline Research Triangle Park, NC 27709, USA Correspondence should be addressed to Antonella Napolitano, antonella.2.napolitano@ Received 17 May 2010; Accepted 6 July 2010 Academic Editor: L. Van Gaal Copyright © 2011 Antonella Napolitano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Evidence of active brown adipose tissue in human adults suggests that this may become a pharmacological target to induce negative energy balance. We have explored whole-body indirect calorimetry to detect the metabolic effects of thermogenic drugs through administration of ephedrine hydrochloride and have assessed ephedrine’s merits as a comparator compound in the evaluation of novel thermogenic agents. Volunteers randomly given ephedrine hydrochloride 15 mg QID (n = 8) or placebo (n = 6) were studied at baseline and after 1-2 and 14-15 days of treatment. We demonstrate that