atherosclerotic plaque stability is affected by the chemokine cxcl10 in both mice and humans动脉粥样硬化斑块稳定性的影响趋化因子cxcl10在老鼠和人类.pdfVIP

SAGE-Hindawi Access to Research International Journal of Inflammation Volume 2011, Article ID 936109, 9 pages doi:10.4061/2011/936109 Research Article Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans Dolf Segers,1 Jonathan A. Lipton,1 Pieter J. M. Leenen,2 Caroline Cheng,1 Dennie Tempel,1 Gerard Pasterkamp,3 Frans L. Moll,4 Rini de Crom,5 and Rob Krams6 1 Department of Cardiology, Erasmus University Medical Center, 3522ZZ Rotterdam, The Netherlands 2 Department of Immunology, Erasmus University Medical Center, 3522ZZ Rotterdam, The Netherlands 3 Department of Cardiology, University Medical Center-Utrecht, 3584CX Utrecht, The Netherlands 4 Department of Vascular Surgery, University Medical Center-Utrecht, 3584CX Utrecht, The Netherlands 5 Department of Cell Biology and Genetics, Erasmus University Medical Center, 3522ZZ Rotterdam, The Netherlands 6 Department of Bioengineering, Royal School of Mines, Imperial College, London SW7 2AZ, UK Correspondence should be addressed to Rob Krams, r.krams@imperial.ac.uk Received 29 June 2011; Accepted 25 August 2011 Academic Editor: Elena Aikawa Copyright © 2011 Dolf Segers et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. The chemokine CXCL10 is specifically upregulated during experimental development of plaque with an unstable phenotype. In this study we evaluated the functional consequences of these findings in mice and humans. Methods and Results. In ApoE−/ − mice, we induced unstable plaque with using a flow-altering device around the carotid artery. From week 1 to 4, mice