atopic dermatitis-like skin lesions reduced by topical application and intraperitoneal injection of hirsutenone in ncnga mice过敏性dermatitis-like皮肤损伤减少局部应用和腹腔内注射的hirsutenone ncnga老鼠.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2010, Article ID 618517, 7 pages doi:10.1155/2010/618517 Research Article Atopic Dermatitis-Like Skin Lesions Reduced by Topical Application and Intraperitoneal Injection of Hirsutenone in NC/Nga Mice Mi Sook Jeong,1 Sun Eun Choi,2 Ji Young Kim,1 Jung Shim Kim,1 Eun Joo Kim,1 Kwan Hee Park,2 Do Ik Lee,2 Seong Soo Joo,3 Chung Soo Lee,1 Hyoweon Bang,1 Mi-Kyung Lee,1 Young Wook Choi,1 Kap-sok Li,1 Nam Ju Moon,1 Min Won Lee,2 and Seong Jun Seo1 1 Department of Dermatology, College of Medicine, Chung-Ang University, Seoul 156-756, Republic of Korea 2 College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea 3 Division of Marine Molecular Biotechnology, Gangneung-Wonju National University, 120 Gangneung Daehangno, Gangneung, Gangwon 210-702, Republic of Korea Correspondence should be addressed to Min Won Lee, mwlee@cau.ac.kr and Seong Jun Seo, drseo@cau.ac.kr Received 3 June 2010; Revised 5 October 2010; Accepted 15 October 2010 Academic Editor: Kurt Blaser Copyright © 2010 Mi Sook Jeong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Atopic dermatitis (AD) is a common inflammatory skin disease. The increasing prevalence and severity of AD have prompted the developments of safer, more effective drugs. Although topical corticosteroids have been used as first line therapy for AD, their potential side effects limit their clinical applications. To investigate the effect of hirsutenone (HIR), a diarylheptanoid compound, on AD-like skin lesions and other factors related to immune response is the aim of this p