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auto-presentation of staphylococcal enterotoxin a by mouse cd4+ t cells葡萄球菌肠毒素a的auto-presentation小鼠cd4 + t细胞.pdf

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auto-presentationofstaphylococcalenterotoxinabymousecd4tcells葡萄球菌肠毒素a的auto-presentation小鼠cd4t细胞

Vol.1, No.1, 8-14 (2011) Open Journal of Immunology doi:10.4236/oji.2011.11002 Auto-presentation of Staphylococcal enterotoxin A by mouse CD4+ T cells + —Auto-presentation by CD4 T cells * Reuven Rasooly , Paula M. Do, Bradley J. Hernlem * Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, USA; Corresponding Author: reuven.rasooly@ Received 27 May 2011, revised 12 June 2011, accepted 20 June 2011. ABSTRACT logical activities: they cause gastroenteritis in the gas- trointestinal tract and act as a superantigen (SAg) caus- The currently accepted model for superantigen ing massive activation and proliferation of T-cells and (SAg) induced T cell activation suggests that cytokine release [1]. Several studies have shown that SAg, without being processed, cross link both there is a relation between emetic and superantigenic MHC class II, from Antigen Presenting Cells activities [2,3]. SAg plays an important role in patho- (APC), and V-, from T-cell receptor (TCR), initi- genesis by undermining th