baculovirus molecular insights on their diversity and conservation杆状病毒的多样性和保护分子的见解.pdfVIP

SAGE-Hindawi Access to Research International Journal of Evolutionary Biology Volume 2011, Article ID 379424, 15 pages doi:10.4061/2011/379424 Review Article Baculovirus: Molecular Insights on Their Diversity and Conservation ´ ´ Solange Ana Belen Miele, Matıas Javier Garavaglia, Mariano Nicolas Belaich, and Pablo Daniel Ghiringhelli LIGBCM (Laboratorio de Ingenier´ıa Gen´etica y Biolog´ıa Celular y Molecular), Departamento de Ciencia y Tecnolog´ıa, Universidad Nacional de Quilmes, Roque Saenz Pe˜na 352, Bernal, Argentina Correspondence should be addressed to Pablo Daniel Ghiringhelli, pdghiringhelli@ Received 15 October 2010; Revised 4 January 2011; Accepted 14 February 2011 Academic Editor: Kenro Oshima Copyright © 2011 Solange Ana Belen Miele et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Baculoviridae is a large group of insect viruses containing circular double-stranded DNA genomes of 80 to 180 kbp. In this study, genome sequences from 57 baculoviruses were analyzed to reevaluate the number and identity of core genes and to understand the distribution of the remaining coding sequences. Thirty one core genes with orthologs in all genomes were identified along with other 895 genes differing in their degrees of representation among reported genomes. Many of these latter genes are common to well-defined lineages, whereas others are unique to one or a few of the viruses. Phylogenetic analyses based on core gene sequences and the gene composition of the genomes