beneficial effects of fumaria indica on chronic stress-induced neurobehavioral and biochemical perturbations in rats有利影响fumaria籼稻的慢性应激大鼠神经行为和生化的扰动.pdfVIP

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beneficial effects of fumaria indica on chronic stress-induced neurobehavioral and biochemical perturbations in rats有利影响fumaria籼稻的慢性应激大鼠神经行为和生化的扰动.pdf

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beneficial effects of fumaria indica on chronic stress-induced neurobehavioral and biochemical perturbations in rats有利影响fumaria籼稻的慢性应激大鼠神经行为和生化的扰动

Chinese Medicine, 2012, 3, 49-60 /10.4236/cm.2012.31009 Published Online March 2012 (http://www.SciRP.org/journal/cm) Beneficial Effects of Fumaria indica on Chronic Stress-Induced Neurobehavioral and Biochemical * Perturbations in Rats 1 2 3† 1# Gireesh Kumar Singh , Geeta Rai , Shyam Sunder Chatterjee , Vikas Kumar 1 Neuropharmacology Research Laboratory, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India 2Department of Molecular and Human Genetics, Faculty of Science, Banaras Hindu University, Varanasi, India 3Stettiner Str. 1, D-76138 Karlsruhe, Germany Email: #vikas.phe@itbhu.ac.in Received September 30, 2011; revised November 17, 2011; accepted November 28, 2011 ABSTRACT Objective: To evaluate the anti-stress activity of standardized extract of Fumaria indica (FI) through validated behav- ioral models of rodents followed by estimation of biochemical changes associated with chronic stress. Methods: Fifty percent ethanolic extract of FI used in this study was standardized on its contents of fumaric acid and its conjugates (0.45% and 0.35% respectively). Stressed Charles Foster rats received unpredictable foot shocks (2 mA, 1 hr, 14 days) through electric grid. FI was given orally as 0.3% carboxymethyl cellulose (CMC) suspension in 100, 200 and 400 mg/kg doses. For comparison, Panax ginseng (PG) ext