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benefits of dedifferentiated stem cells for neural regeneration肉瘤干细胞神经再生的好处
Vol.2, No.3, 108-121 (2012) Stem Cell Discovery
/10.4236/scd.2012.23016
Benefits of dedifferentiated stem cells for neural
regeneration
1,2,3# 4# 1,2 3 1,2*
Yinda Tang , Wen Xu , Haiying Pan , Shiting Li , Yong Li
1
Department of Pediatric Surgery, School of Medicine, University of Texas, Houston, USA;
*
Corresponding Author: Yong.Li.1@
2Center for Stem Cell and Regenerative Medicine, The University of Texas Health Science Center at Houston, Houston, USA
3Department of Neurosurgery, Shanghai Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
4Center for Neuroscience, University of Pittsburgh, Pittsburgh, USA
Received 11 April 2012; revised 11 May 2012; accepted 10 June 2012
ABSTRACT tive phenomena have been sought after for decades. De-
differentiation, which is one process involved in natural
Dedifferentiation, as one of the mechanisms
regeneration, refers to the reversion of a terminally dif-
rerouting cell fate, regresses cells from a dif-
ferentiated cell back to a less differentiated stage within
ferentiated status to a more primitive one. Due to
its own lineage as part of regenerative process. It was
its potential of amplifying the stem/progenitor
cell pool and reproducing sizable and desirable first used to describe ascidian stolon regeneration in
cellular e
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