原创力文档autoantibodies to apolipoprotein a-1 in cardiovascular diseases current perspectives自身抗体与载脂蛋白a - 1在心血管疾病当前的观点.pdfVIP
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autoantibodies to apolipoprotein a-1 in cardiovascular diseases current perspectives自身抗体与载脂蛋白a - 1在心血管疾病当前的观点
Hindawi Publishing Corporation
Clinical and Developmental Immunology
Volume 2012, Article ID 868251, 7 pages
doi:10.1155/2012/868251
Review Article
Autoantibodies to Apolipoprotein A-1 in Cardiovascular Diseases:
Current Perspectives
P. C. Teixeira,1, 2 P. Cutler,1 and N. Vuilleumier2, 3, 4
1 Translational Research Sciences, F.n Hoff man-La Roche Ltd., 4070 Basel, Switzerland
2 Department of Human Protein Science, Geneva Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland
3 Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospital Geneva,
1211 Geneva, Switzerland
4 Laboratory Medicine Service, Department of Genetics and Laboratory Medicine, Geneva University Hospital,
4 Rue Gabrielle-Perret-Gentil, 1211 Geneva, Switzerland
Correspondence should be addressed to N. Vuilleumier, nicolas.vuilleumier@hcuge.ch
Received 2 October 2012; Accepted 19 October 2012
Academic Editor: Dimitrios P. Bogdanos
Copyright © 2012 P. C. Teixeira et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Immune-mediated inflammation plays a major role in atherosclerosis and atherothrombosis, two essential features for
cardiovascular disease (CVD) development, currently considered as the leading cause of death in the western world. There is
accumulating evidence showing that humoral autoimmunity might play an important role in CVD and that some autoantibodies
could represent emerging cardiovascular risk factors. Recent studies demonstrate that IgG autoantibodies against apolipoprotein
A-1 (apoA-1) are raised in many diseases associat
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