原创力文档association of adverse effects with monoamine oxidase type b inhibitor and catechol-o-methyl transferase inhibitor combination therapy in parkinson’s disease patients协会的不利影响与单胺氧化酶b型抑制剂和catechol-o-methyl转移酶抑制剂联合治疗帕金森症患者.pdfVIP
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association of adverse effects with monoamine oxidase type b inhibitor and catechol-o-methyl transferase inhibitor combination therapy in parkinson’s disease patients协会的不利影响与单胺氧化酶b型抑制剂和catechol-o-methyl转移酶抑制剂联合治疗帕金森症患者
Vol.1, No.1, 5-10 (2012) Advances in Parkinson’s Disease
doi:10.4236/apd.2012.11002
Association of adverse effects with monoamine
oxidase type B inhibitor and catechol-o-methyl
transferase inhibitor combination therapy in
Parkinson’s disease patients
*
Rui Zhang, Danielle C. Spengler, Marie-Helene Saint-Hilaire , Anna D. Hohler
Department of Neurology, Boston University School of Medicine, Boston, USA;
*
Corresponding Author: Marie.Saint-Hilaire@
Received 1 July 2012; revised 24 July 2012; accepted 22 August 2012
ABSTRACT 1. INTRODUCTION
Currently, levodopa is the most effective and Parkinson’s disease (PD) is a neurodegenerative disorder
commonly used medication to control motor [1], characterized by resting tremor, rigidity or stiffness,
symptoms in Parkinson’s disease (PD). However, bradykinesia and postural instability [2]. While the eti-
its long-term use is associated with adverse effects ology of PD remains uncertain [3,4], the progressive loss
(AEs). Combination therapy of a monoamine of dopaminergic neurons in the substantia nigra (SN) is
oxidase type B inhibitor (MAOBI) with levodopa considered a marker of the motor disorder of PD [5].
or a catechol-O-methyl transferase inhibitor (COMTI) Currently, medication therapy is the most widely used
with levodopa provides benefits to PD patients. treatment for PD. Several types of medications have been
Direct comparison of efficacy and side effect approved by the US Food and Drug Administration (FDA)
profiles is complex. The aim of this study is to
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