association of autoantibodies to bp180 with disease activity in greek patients with bullous pemphigoid协会的自身抗体与疾病活动bp180希腊大疱类天疱疮患者.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 854795, 4 pages doi:10.1155/2012/854795 Research Article Association of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous Pemphigoid Aikaterini Patsatsi,1 Aikaterini Kyriakou,1 Aikaterini Pavlitou-Tsiontsi,2 Anastasia Giannakou,2 and Dimitrios Sotiriadis1 1 2nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Aristotle University School of Medicine, Nea Eflkarpia, Ring Road Thessalonikis, 56403 Thessaloniki, Greece 2 Immunology Laboratory, Papageorgiou General Hospital, Nea Eflkarpia, Ring Road Thessalonikis, 56403 Thessaloniki, Greece Correspondence should be addressed to Aikaterini Kyriakou, docmouli@ Received 7 September 2012; Revised 24 October 2012; Accepted 25 October 2012 Academic Editor: Dimitrios P. Bogdanos Copyright © 2012 Aikaterini Patsatsi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 39 bullous pemphigoid (BP) patients were studied to assess the clinical significance of anti-BP180 and anti-BP230 circulating autoantibodies of BP and correlate their titers with the clinical scores of the BP Disease Area Index (BPDAI) and the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) as well as with the intensity of pruritus measured by the BPDAI pruritus component. All parameters were evaluated by the time of diagnosis (baseline), month 3, and month 6. Titers of anti-BP180 autoantibodies were strongly correlated with BPDAI (r = 0.557, P value 0.0001) and ABSIS (r = 0.570, P value 0.0001) values, as well as with BPDAI component f