association of mcp-1 -2518 ag single nucleotide polymorphism with the serum level of crp in slovak patients with ischemic heart disease, angina pectoris, and hypertension协会mcp-1 -2518 ag)单核苷酸多态性与血清c反应蛋白水平在斯洛伐克缺血性心脏病患者,心绞痛和高血压.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2009, Article ID 390951, 6 pages doi:10.1155/2009/390951 Clinical Study Association of MCP-1 -2518 A/G Single Nucleotide Polymorphism with the Serum Level of CRP in Slovak Patients with Ischemic Heart Disease, Angina Pectoris, and Hypertension Maria Bucova,1 Jan Lietava,2 Peter Penz,3 Frantisek Mrazek,4 Jana Petrkova,5 Marian Bernadic,6 and Martin Petrek4 1 Institute of Immunology, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia 2 Department of Internal Medicine II, Faculty of Medicine, Comenius University, 813 69 Bratislava, Slovakia 3 Department of Internal Medicine I, Faculty of Medicine, Comenius University, 813 69 Bratislava, Slovakia 4 Laboratory of Immunogenomics, Department of Immunology, Faculty of Medicine, Palacky University, 77 900 Olomouc, Czech Republic 5 Department of Internal Medicine I, Faculty Hospital, 77 900 Olomouc, Czech Republic 6 Institute of Pathological Physiology, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia Correspondence should be addressed to Maria Bucova, maria.bucova@ Received 29 May 2009; Accepted 29 May 2009 Recommended by Sunit Kumar Singh The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group of healthy subjects. Totally, 263 patients with the diagnosis of IHD, out of them 89 with MI, 145 with AP, 205 with HT, and also 67 healthy subjects were included in the study. First, we estimated the serum levels of hsCRP. We found that patients with AP had significa