association of inflammatory and oxidative stress markers with metabolic syndrome in asian indians in india炎症和氧化应激标志物代谢综合症协会在印度在亚洲的印度人.pdfVIP

SAGE-Hindawi Access to Research Cardiology Research and Practice Volume 2011, Article ID 295976, 8 pages doi:10.4061/2011/295976 Research Article Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India Veena S. Rao,1 Radhika K. Nagaraj,2 Sridhara Hebbagodi,2 Natesha B. Kadarinarasimhiah,1 and Vijay V. Kakkar1, 2 1 Tata Proteomics and Coagulation Unit, Thrombosis Research Institute, Narayana Hrudayalaya, 258/A Bommasandra Industrial Area, Anekal Taluk, Bangalore 560099, India 2 Emmanuel Kaye Bioinformatics Centre, Thrombosis Research Institute, Bangalore 560099, India Correspondence should be addressed to Veena S. Rao, veenasrao@.in Received 30 September 2010; Revised 29 October 2010; Accepted 5 November 2010 Academic Editor: Rei Shibata Copyright © 2011 Veena S. Rao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Metabolic syndrome (MetS) is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the Indian Atherosclerosis Research Study (IARS). Modified ATPIII guidelines were used for classification of subjects with MetS. Among the inflammatory and oxidative stress markers studied, levels of hsCRP (P .0001), Neopterin (P = .036), and oxLDL (P .0001) were significantly higher among subjects with MetS. Among the markers we tested, oxLDL stood out as a robust predictor of MetS in the IARS population (OR 4.956 95% CI 2.504–9.810; P .0001) followed by