association of polymorphisms in the human il4 and il5 genes with atopic bronchial asthma and severity of the disease协会在人类il4和il5基因多态性与支气管哮喘和过敏性疾病的严重程度.pdfVIP

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association of polymorphisms in the human il4 and il5 genes with atopic bronchial asthma and severity of the disease协会在人类il4和il5基因多态性与支气管哮喘和过敏性疾病的严重程度.pdf

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association of polymorphisms in the human il4 and il5 genes with atopic bronchial asthma and severity of the disease协会在人类il4和il5基因多态性与支气管哮喘和过敏性疾病的严重程度

Comparative and Functional Genomics Comp Funct Genom 2003; 4: 346–350. Published online in Wiley InterScience (). DOI: 10.1002/cfg.293 Short Communication Association of polymorphisms in the human IL4 and IL5 genes with atopic bronchial asthma and severity of the disease 1 2 2 1,3 Maxim B. Freidin , Olga S. Kobyakova , Ludmila M. Ogorodova and Valery P. Puzyrev * 1Population Genetics Laboratory, Research Institute for Medical Genetics, Tomsk, Russia 2 Department of Pediatrics, Siberian State Medical University, Tomsk, Russia 3Department of Medical Genetics, Siberian State Medical University, Tomsk, Russia *Correspondence to: Abstract Valery P. Puzyrev, Research Institute for Medical Genetics, 10 Two polymorphisms in the IL4 (G/C 3 -UTR) and IL5 (C-703T) genes were studied in Nab. r. Ushaiky Ave., 634050 a sample of families whose probands had atopic bronchial asthma (BA) (66 families, Tomsk, Russia. n = 183) and in a group of non-cognate individuals with the severe form of the disease E-mail: valery@img.tsu.ru. (n = 34). The samples were collected from the Russian population in the city of Tomsk (Russia). Using the transmission/disequilibrium test (TDT), a signiﬁcant association of allele C-703 IL5 with BA was established (TDT = 4.923, p = 0.007 ± 0.0007). The analysis of 40 individuals with mild asthma and 49 patients with the severe form of the disease revealed a negative association of genotype GG IL4 (OR = 0.39, 95% CI = 0.15–0.99, p