原创力文档association of morphology and immunophenotype in diffuse large b-cell lymphomas with bone marrow infiltration in a sample mexican population协会的形态学和immunophenotype弥漫型大b细胞淋巴瘤骨髓浸润在墨西哥人口样本.pdfVIP
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association of morphology and immunophenotype in diffuse large b-cell lymphomas with bone marrow infiltration in a sample mexican population协会的形态学和immunophenotype弥漫型大b细胞淋巴瘤骨髓浸润在墨西哥人口样本
Open Journal of Pathology, 2012, 2, 29-37 29
Published Online April 2012 (http://www.SciRP.org/journal/ojpathology)
/10.4236/ojpathology.2012.22007
Association of Morphology and Immunophenotype in
Diffuse Large B-Cell Lymphomas with Bone Marrow
*
Infiltration in a Sample Mexican Population
1# 1 1
Mónica-Belinda Romero-Guadarrama , Fiacro Jiménez Ponce , Armando Medina Cruz ,
Elsa Lorena Durán Ramírez1, Icela Palma Lara2
1Unidad de Patología del Hospital General de México, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM),
México City, México; 2Molecular and Celular Morphology Laboratory, Escuela Superior de Medicina, Instituto Politécnico Nacional
and Morphology Department, Facultad de Medicina Veterinaria y Zootecnia (UNAM), México City, México.
Email: #monicaromero@.mx
Received January 26th, 2012; revised February 10th, 2012; accepted March 12th, 2012
ABSTRACT
Introduction: Diffuse large B-cell lymphoma (DLBCL), not otherwise specified, is a large B-cell lymphoma with a
diffuse growth pattern and aggressive clinical course. It is divided in subgroups according to its morphology, immuno-
phenotype, and primary site. Dissemination to bone marrow occurs in 11% to 35% of cases and can be of concordant or
discordant morphology. Objective: To examine the association, the type of bone marrow involvement in relation to the
primary site, morphology, immunohistochemistry of DLBCLs and to determine the cases of Epstein-Barr virus positive
DLBCLs. Materials and Methods: We reviewed lymph node and extranodal biopsies as well as the respective bone
marrow biopsies in all cases of DLBCL diagnosed in the Hospital
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