原创力文档association of cyp2b6 genotype with survival and progression free survival in cyclophosphamide treated multiple myeloma协会cyp2b6基因型与生存和发展自由生存在环磷酰胺治疗多发性骨髓瘤.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
association of cyp2b6 genotype with survival and progression free survival in cyclophosphamide treated multiple myeloma协会cyp2b6基因型与生存和发展自由生存在环磷酰胺治疗多发性骨髓瘤
Journal of Cancer Therapy, 2012, 3, 20-27
/10.4236/jct.2012.31003 Published Online February 2012 (http://www.SciRP.org/journal/jct)
Association of CYP2B6 Genotype with Survival and
Progression Free Survival in Cyclophosphamide
Treated Multiple Myeloma
1 1,2 3 4 1,5
Ingrid Jakobsen Falk , Muhammad Suleman Khan , Lena Thunell , Hareth Nahi , Henrik Gréen
1Division of Drug Research, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköpings University,
Linköping, Sweden; 2Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan; 3Department
of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköpings University, Linköping, Sweden; 4Department of
Hematology, Karolinska University Hospital and Karolinska Institute, Huddinge, Sweden; 5Science for Life Laboratory, School of
Biotechnology, Division of Gene Technology, Royal Institute of Technology, Solna, Sweden.
Email: Ingrid.jakobsen.falk@liu.se
Received November 7th, 2011; revised December 9th, 2011; accepted December 20th, 2011
ABSTRACT
Objective: Cyclophosphamide is a conventional pro-drug used in Multiple Myeloma (MM) and other malignancies.
The highly polymorphic CYP2B6 is suggested as a major contributor in cyclophosphamide bioactivation, and GST en-
zymes are involved in detoxification. Polymorphisms of these enzymes may affect enzyme expression and function as
well as treatment outcome. The aim of this study was to investigate the impact of the CYP2B6 SNPs G516T, A785G
and C1459T, GSTP1 SNP Ile105Val, and GSTM1 and GSTT1 null variants, on the outcome for cyclophosphamide
treated MM patients, in order to find markers of value for individualised therapy. Methods: We used alle
您可能关注的文档
- approximation of bounded variation functions by a bézier variant of the bleimann, butzer, and hahn operators有界变差函数的近似的贝塞尔曲线变体bleimann,一部,哈恩运营商.pdf
- approximation of homomorphisms and derivations on non-archimedean lie -algebras via fixed point method近似的同态和推导非阿基米德躺代数通过定点的方法.pdf
- approximation of fixed points of strongly pseudocontractive mappings in uniformly smooth banach spaces近似强烈pseudocontractive映射的不动点均匀光滑的巴拿赫空间.pdf
- approximating ideal filters by systems of fractional order分数阶系统的近似理想的过滤器.pdf
- approximation order for multivariate durrmeyer operators with jacobi weights近似为多元durrmeyer运营商与雅可比权重.pdf
- approximation of the pth roots of a matrix by using trapezoid rule矩阵的近似的甲状旁腺素根用梯形法则.pdf
- approximation of mixed-type functional equations in menger pn-spaces在门格尔pn-spaces混合型函数方程的近似.pdf
- approximation for the finite-time ruin probability of a general risk model with constant interest rate and extended negatively dependent heavy-tailed claims近似的限定时间一般风险模型的破产概率与常数利率和扩展消极依赖重尾分布要求.pdf
- approximation of signals (functions) belonging to the weighted -class by linear operators近似的信号(函数)属于线性算子的加权海尔集团.pdf
- aptasensors in health, environment and food safety monitoringaptasensors在卫生、环境和食品安全的监控.pdf
- assessment of the ionospheric and tropospheric effects in location errors of data collection platforms in equatorial region during high and low solar activity periods电离层和对流层效果的评估数据收集平台的位置错误在赤道地区在高、低太阳活动周期.pdf
- association of autoantibodies to bp180 with disease activity in greek patients with bullous pemphigoid协会的自身抗体与疾病活动bp180希腊大疱类天疱疮患者.pdf
- association of gst genes polymorphisms with asthma in tunisian children协会的gst基因多态性与突尼斯儿童的哮喘.pdf
- association of human herpesvirus 6 and 8 in relapsing remitting multiple sclerosis type during exacerbation人类疱疹病毒6和8协会复发汇款多发性硬化症类型在恶化.pdf
- association of genetic variation in the promoter region of oxtr with differences in social affective neural processing协会的启动子区域基因变异oxtr社会情感神经的差异处理.pdf
- association of c-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome协会的c反应蛋白,脂联素受体拮抗剂及代谢综合征.pdf
- association of mitral annulus calcification with high-sensitivity c-reactive protein, which is a marker of inflammation协会的二尖瓣环钙化和高敏c反应蛋白,这是一种炎症的标志.pdf
- association of morphology and immunophenotype in diffuse large b-cell lymphomas with bone marrow infiltration in a sample mexican population协会的形态学和immunophenotype弥漫型大b细胞淋巴瘤骨髓浸润在墨西哥人口样本.pdf
- association of mcp-1 -2518 ag single nucleotide polymorphism with the serum level of crp in slovak patients with ischemic heart disease, angina pectoris, and hypertension协会mcp-1 -2518 ag)单核苷酸多态性与血清c反应蛋白水平在斯洛伐克缺血性心脏病患者,心绞痛和高血压.pdf
- association of polymorphisms in the human il4 and il5 genes with atopic bronchial asthma and severity of the disease协会在人类il4和il5基因多态性与支气管哮喘和过敏性疾病的严重程度.pdf
文档评论（0）