aurones a promising heterocyclic scaffold for the development of potent antileishmanial agentsaurones有前途的杂环支架的发展强有力的antileishmanial代理.pdfVIP

下载本文档

1
0
约6.64万字
约 9页
2017-08-27 发布于上海
举报
版权申诉

aurones a promising heterocyclic scaffold for the development of potent antileishmanial agentsaurones有前途的杂环支架的发展强有力的antileishmanial代理.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

aurones a promising heterocyclic scaffold for the development of potent antileishmanial agentsaurones有前途的杂环支架的发展强有力的antileishmanial代理

Hindawi Publishing Corporation International Journal of Medicinal Chemistry Volume 2012, Article ID 196921, 8 pages doi:10.1155/2012/196921 Research Article Aurones: A Promising Heterocyclic Scaffold for the Development of Potent Antileishmanial Agents Marina Roussaki,1 Soﬁa Costa Lima,2 Anna-Maria Kypreou,1 Panagiotis Kefalas,3 Anabela Cordeiro da Silva,2, 4 and Anastasia Detsi1 1 Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Heroon Polytechniou 9, Zografou Campus, 15780 Athens, Greece 2 Parasite Disease Group, IBMC-Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal 3 Department of Food Quality and Chemistry of Natural Products, Mediterranean Agronomic Institute of Chania, International Centre for Advanced Mediterranean Agronomic Studies, 73100 Chania, Crete, Greece 4 Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreiera, 228, 4050-313 Porto, Portugal Correspondence should be addressed to Anastasia Detsi, adetsi@chemeng.ntua.gr Received 27 May 2012; Accepted 31 July 2012 Academic Editor: O. Bruno Copyright © 2012 Marina Roussaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A series of (Z )-2-benzylidenebenzofuran-3-(2H)-ones (aurones) bearing a variety of substituents on rings A and B were synthesized and evaluated for their antiparasitic activity against the intracellular amastigote form of Leishmania infantum and their cytotoxicity against human THP1-diﬀ