原创力文档autoantibodies to tailor-made panels of tumor-associated antigens in breast carcinoma自身抗体定制面板乳腺癌的肿瘤相关抗原.pdfVIP
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autoantibodies to tailor-made panels of tumor-associated antigens in breast carcinoma自身抗体定制面板乳腺癌的肿瘤相关抗原
Hindawi Publishing Corporation
Journal of Oncology
Volume 2011, Article ID 982425, 7 pages
doi:10.1155/2011/982425
Review Article
Autoantibodies to Tailor-Made Panels of Tumor-Associated
Antigens in Breast Carcinoma
Ettie Piura1 and Benjamin Piura2
1 Department of Obstetrics and Gynecology, Sapir Medical Center, Sackler School of Medicine, University of Tel-Aviv,
Kfar-Saba 44281, Israel
2 Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Soroka Medical Center and Faculty of Health Sciences,
Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Correspondence should be addressed to Benjamin Piura, piura@bgu.ac.il
Received 31 October 2010; Accepted 14 January 2011
Academic Editor: Aysegula A. Sahin
Copyright © 2011 E. Piura and B. Piura. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Autoantibodies (AAbs) to tumor-associated antigens (TAAs) have been identified in the sera of cancer patients. In a previous
review published in this journal, we have focused on recent knowledge related to circulating AAbs to individual TAAs in breast
carcinoma. This review will focus on recent knowledge related to AAb assays to tailor-made panels of TAAs in breast carcinoma.
So far, AAb assays to the following tailor-made panels of TAAs have been assessed in breast carcinoma: (1) p53, c-myc, HER2, NY-
ESO-1, BRCA2, and MUC1, (2) IMP1, p62, Koc, p53, c-MYC, cyclin B1, and survivin, (3) PPIA, PRDX2, FKBP52, HSP-60, and
MUC1, (4) MUC1, HER2, p53, and IGFBP2, (5) p53, HER2, IGFBP-2, and TOPO2α, (6) survivin and livin, (7) ASB-9, SERAC1,
and RELT, and (8) p16, p53, and
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