biomechanical prediction of abdominal aortic aneurysm rupture risk sensitivity analysis生物力学预测腹主动脉瘤破裂风险敏感性分析.pdfVIP

J. Biomedical Science and Engineering, 2012, 5, 664-671 JBiSE / 10.4236/jbise.2012.511083 Published Online November 2012 (http://www.SciRP.org/journal/jbise/) Biomechanical prediction of abdominal aortic aneurysm rupture risk: Sensitivity analysis 1 1 1,2* Shijia Zhao , Wenlong Li , Linxia Gu 1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, USA 2Nebraska Center for Materials and Nanoscience, Lincoln, USA * Email: lgu2@ Received 30 July 2012; revised 13 September 2012; accepted 20 September 2012 ABSTRACT reported a rupture rate of 12.8% for AAAs with a maxi- mum diameter less than 5 cm and 40% for AAAs with a Objectives: The purpose of this research is to deter- diameter larger than 5 cm in an autopsy study [3]. Hall et mine the quantitative relationship between the peak al. observed that the rupture rate for AAAs with a maxi- wall stress of abdominal aortic aneurysm (AAA) and mum diameter less than 5 cm could be up to 23% [4]. its clinical risk factors including its maximum diame- The high mortality associated with the AAA rupture ter, asymmetry index, wall thickness and abnormal and the inaccuracy of the traditional 5-cm criterion need high blood pressure. Methods: The response surface