blm deficiency is not associated with sensitivity to hydroxyurea-induced replication stressblm缺乏与灵敏度hydroxyurea-induced复制压力无关.pdfVIP

SAGE-Hindawi Access to Research Journal of Nucleic Acids Volume 2010, Article ID 319754, 8 pages doi:10.4061/2010/319754 Research Article BLM Deficiency Is Not Associated with Sensitivity to Hydroxyurea-Induced Replication Stress 1, 2 ´ ` 1, 2 1, 2 Kenza Lahkim Bennani-Belhaj, Geraldine Buhagiar-Labarchede, Nada Jmari, 1, 2 ´ 1, 2 Rosine Onclercq-Delic, and Mounira Amor-Gueret 1 Institut Curie, Centre de Recherche, Centre Universitaire, Bat. 110, 91405 Orsay, France ˆ 2 CNRS, UMR 3348, 91405 Orsay, France ´ Correspondence should be addressed to Mounira Amor-Gueret, mounira.amor@curie.u-psud.fr Received 11 May 2010; Accepted 19 July 2010 Academic Editor: Ashis Basu Copyright © 2010 Kenza Lahkim Bennani-Belhaj et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Bloom’s syndrome (BS) displays one of the strongest known correlations between chromosomal instability and a high risk of cancer at an early age. BS cells combine a reduced average fork velocity with constitutive endogenous replication stress. However, the response of BS cells to replication stress induced by hydroxyurea (HU), which strongly slows the progression of replication forks, remains unclear due to publication of confli