b-cell pathology in juvenile idiopathic arthritisb细胞在青少年特发性关节炎病理.pdfVIP

Hindawi Publishing Corporation Arthritis Volume 2010, Article ID 759868, 6 pages doi:10.1155/2010/759868 Review Article B-Cell Pathology in Juvenile Idiopathic Arthritis V. Wiegering,1, 2 H. J. Girschick,2, 3 and H. Morbach2 1 Pediatric Hematology, Oncology and Neurooncology, Pediatric Stem Cell Transplantation Program, Children’s Hospital, University of Wurzburg, Josef-Schneider-Str. 2, 97080 Wurzburg, Germany ¨ ¨ 2 Pediatric Rheumatology, Immunology and Infectious Diseases, Children’s Hospital, University of Wurzburg, ¨ Josef-Schneider-Str. 2, 97080 W urzburg, Germany ¨ 3 Vivantes Children’s Hospital, Friedrichshain, Landsberger Allee 49, 10249 Berlin, Germany Correspondence should be addressed to H. Morbach, morbach h@klinik.uni-wuerzburg.de Received 29 September 2010; Accepted 4 November 2010 Academic Editor: Ruben Burgos-Vargas Copyright © 2010 V. Wiegering et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Juvenile Idiopathic Arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of different diseases. Due to the promising results of B-cell depleting therapies in rheumatoid arthritis the role of B-cells in autoimmune diseases has to be discussed in a new context. Additionally, experiments in mouse models have shed new light on the antibody-independent role of B-cells in the development of autoimmune d