breast cancer small molecules targeting apoptosis, a prospective approach to safe scientific success乳腺癌的小分子靶向细胞凋亡,前瞻性方法安全科学的成功.pdfVIP

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breast cancer small molecules targeting apoptosis, a prospective approach to safe scientific success乳腺癌的小分子靶向细胞凋亡,前瞻性方法安全科学的成功.pdf

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breast cancer small molecules targeting apoptosis, a prospective approach to safe scientific success乳腺癌的小分子靶向细胞凋亡,前瞻性方法安全科学的成功

Advances in Bioscience and Biotechnology, 2012, 3, 833-844 ABB /10.4236/abb.2012.37104 Published Online November 2012 (http://www.SciRP.org/journal/abb/) Breast cancer: Small molecules targeting apoptosis, a prospective approach to safe scientific success 1 1 2 3 3,4 Mpho Choene , Nonkululeko Mthembu , Zodwa Dlamini , Matlou Mokgotho , James Wachira , Lesetja Motadi1* 1School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, South Africa 2Faculty of Science, University of South Africa, Pretoria, South Africa 3Department of Biochemistry, University of Limpopo, Sovenga, South Africa 4Department of Biology, Morgan State University, Baltimore, USA * Email: lesetja.motadi@wits.ac.za Received 12 August 2012; revised 13 September 2012; accepted 17 October 2012 ABSTRACT cer cannot be attributed to one factor alone. A number of variables play a role in the development of breast malig- Breast carcinoma represents the second leading cause nancies. Even though it is fairly difficult to pinpoint one of cancer death in developed countries amongst wo- cause as the main risk factor for breast cancer, studies men. Current cytotoxic chemotherapy plays an im- have shown there are certain genetic, reproductive and portant r