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biomedical informatics and granularity生物医学信息学和粒度
Comparative and Functional Genomics
Comp Funct Genom 2004; 5: 501–508.
Published online in Wiley InterScience (). DOI: 10.1002/cfg.429
Conference Paper
Biomedical informatics and granularity
1 1,2 1,2
Anand Kumar *, Barry Smith and Daniel D. Novotny
1 ¨
IFOMIS, University of Saarland, Saarbrucken, Germany
2 Department of Philosophy, University at Buffalo, NY, USA
*Correspondence to: Abstract
Anand Kumar, IFOMIS, University
of Saarland, Postbox 151150, An explicit formal-ontological representation of entities existing at multiple levels
¨ of granularity is an urgent requirement for biomedical information processing. We
D-66041 Saarbrucken, Germany.
E-mail: discuss some fundamental principles which can form a basis for such a representation.
akumar@ifomis.uni-saarland.de We also comment on some of the implicit treatments of granularity in currently
available ontologies and terminologies (GO, FMA, SNOMED CT). Copyright 2004
John Wiley Sons, Ltd.
Received: 4 October 2004
Revised: 12 October 2004 Keywords: clinical bioinformatics; medical informatics; life sciences data integra-
Accepted: 13 October 2004 tion; ontology; knowledge representation; levels of granularity
Organisms, including human beings, consist of a at such finer levels of granularity which are of
variety of anatomical structures which exist at principal interest. If the effective integration of life-
different levels of granularity (also called ‘lev- science data is to be achieved, then we need to do
els of complexity’ or
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