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cisplatin-induced posterior reversible encephalopathy syndrome—brief report and review of the literaturecisplatin-induced后部可逆性脑病syndrome-brief报告和文献之回顾.pdf

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cisplatin-induced posterior reversible encephalopathy syndrome—brief report and review of the literaturecisplatin-induced后部可逆性脑病syndrome-brief报告和文献之回顾

Journal of Behavioral and Brain Science, 2012, 2, 97-101 97 /10.4236/jbbs.2012.21011 Published Online February 2012 (http://www.SciRP.org/journal/jbbs) Cisplatin-Induced Posterior Reversible Encephalopathy * Syndrome—Brief Report and Review of the Literature Limor Amit1,2, Irit Ben-Aharon1,2#, Thomas Tichler1,2, Edna Inbar2,3, Aaron Sulkes1,2, Salomon M. Stemmer1,2 1Institute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Campus, Petah-Tiqva, Israel 2The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 3Department of Radiology, Rabin Medical Center, Beilinson Campus, Petah-Tiqva, Israel Email: #iritbenaharon@ Received July 13, 2011; revised August 28, 2011; accepted October 13, 2011 ABSTRACT Cisplatin is one of the most broadly used chemotherapeutic agents. Several central nervous system toxicities have been attributed to this agent, among which is a rare clinicoradiological condition referred to as posterior reversible leukoen- cephalopathy syndrome (PRES) or reversible posterior leukoencephalopathy syndrome (RPLS). PRES is characterized by subacute onset of headache, visual disturbances, confusion, seizures and rarely, coma. This usually reversible syn- drome was associated in the past mainly with hypertension. Several reports have associated the syndrome with several immunosuppressive and chemotherapeutic agents suggesting a disruption of the blood brain barrier due to direct dam- age to the endothelium and vasogenic edema. This syndrome is readily diagnosed with Computed Tomogra