clostridial spores for cancer therapy targeting solid tumour microenvironment梭菌属的孢子对癌症治疗针对固体肿瘤微环境.pdfVIP

Hindawi Publishing Corporation Journal of Toxicology Volume 2012, Article ID 862764, 8 pages doi:10.1155/2012/862764 Review Article Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment 1 2 ´ 3 4 1 Brittany Umer, David Good, Jozef Anne, Wei Duan, and Ming Q. Wei 1 School of Medical Science and Griffi th Health Institute, Griffi th University, Gold Coast Campus, Southport, QLD 4222, Australia 2 School of Physiotherapy, Australian Catholic University, McAuley Campus, Banyo, QLD 4014, Australia 3 Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium 4 School of Medicine, Deakin University, Waurn Ponds, VIC 3217, Australia Correspondence should be addressed to Ming Q. Wei, m.wei@griffi.au Received 23 December 2011; Accepted 27 January 2012 Academic Editor: Martha L. Hale Copyright © 2012 Brittany Umer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Solid tumour accounts for 90% of all cancers. The current treatment approach for most solid tumours is surgery, however it is limited to early stage tumours. Other treatment options such as chemotherapy and radiotherapy are non-selective, thus causing damage to both healthy and cancerous tissue. Past research has focused on understanding tumour cells themselves, and conventional wisdom has aimed at targeting these cells directly. Recent research has shifted towards understanding the tumour microenvironment and it’s differences from that of health