原创力文档comparative efficacy of tagetes erecta and centella asiatica extracts on wound healing in albino rats比较万寿菊和积雪草提取物的功效在白化大鼠伤口愈合.pdfVIP
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comparative efficacy of tagetes erecta and centella asiatica extracts on wound healing in albino rats比较万寿菊和积雪草提取物的功效在白化大鼠伤口愈合
Chinese Medicine, 2011, 2, 138-142
doi:10.4236/cm.2011.24023 Published Online December 2011 (http://www.SciRP.org/journal/cm)
Comparative Efficacy of Tagetes erecta and Centella
asiatica Extracts on Wound Healing in Albino Rats
1 1* 2 3 1
Sandipan Chatterjee , Tigari Prakash , Dupadahalli Kotrsha , Nadendla Rama Rao , Divakar Goli
1
Department of Pharmacology, Acharya B M Reddy College of Pharmacy, Bangalore, India
2Department of Parasitology, Faculty of Medicine , University of Malaysia, Kuala Lumpur, Malaysia
3Department of Pharmaceutical Chemistry, Chalapathi Institute of Pharmaceutical Science,
Guntur, India
E-mail : prakash_tigari@
Received July 20, 2011; revised August 22, 2011; accepted August 29, 2011
Abstract
The study was undertaken to evaluate the comparative efficacy of hydroalcoholic extracts of leaves of Ta-
getes erecta (T. erecta) and aerial parts of Centella asiatica (C. asiatica) on Excision, Incision and Dead
space wound models in albino rats. Extract of T. erecta and C. asiatica (P 0.001) showed significant in-
crease in rate of wound contraction, epithelization and formation of scar faster in excision wound model
compare to control group. T. erecta extract (250 and 500 mg/kg) showed significantly increased the wound
breaking strength in incision wound model and wet and dry granulation tissue weights, breaking strength in a
dead space wound model compare to control and C. asiatica treated group (P 0.001). In this investigation
the work is conclude that the comparison made between the above two p
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