原创力文档comparison of the genetic organization, expression strategies and oncogenic potential of htlv-1 and htlv-2比较的遗传组织、表达策略和致癌htlv 1和htlv-2的潜力.pdfVIP
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comparison of the genetic organization, expression strategies and oncogenic potential of htlv-1 and htlv-2比较的遗传组织、表达策略和致癌htlv 1和htlv-2的潜力
Hindawi Publishing Corporation
Leukemia Research and Treatment
Volume 2012, Article ID 876153, 14 pages
doi:10.1155/2012/876153
Review Article
Comparison of the Genetic Organization, Expression Strategies
and Oncogenic Potential of HTLV-1 and HTLV-2
Francesca Rende,1 Ilaria Cavallari,1 Maria Grazia Romanelli,2 Erica Diani,2
Umberto Bertazzoni,2 and Vincenzo Ciminale1
1 Department of Oncology and Surgical Sciences, The University of Padova, 35128 Padova, Italy
2 Department of Life and Reproduction Sciences, University of Verona, 37134 Verona, Italy
Correspondence should be addressed to Vincenzo Ciminale, v.ciminale@unipd.it
Received 9 September 2011; Accepted 24 September 2011
Academic Editor: Mineki Saito
Copyright © 2012 Francesca Rende et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Human T cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) are genetically related complex retroviruses that are capable
of immortalizing human T-cells in vitro and establish life-long persistent infections in vivo. In spite of these apparent similarities,
HTLV-1 and HTLV-2 exhibit a significantly different pathogenic potential. HTLV-1 is recognized as the causative agent of adult T-
cell leukemia/lymphoma (ATLL) and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). In contrast, HTLV-
2 has not been causally linked to human malignancy, although it may increase the risk of developing inflammatory neuropathies
and infectious diseases. The present paper is focused on the studies aimed at defining the viral genetic determinants of the
pathobiology of HTLV-1 and
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