combined 18f-fdg petct with enhanced ct perform one-stop shop imaging for assessing pancreatic carcinoma结合18 f-fdg petct与增强ct执行一站式成像评估胰脏癌.pdfVIP

Journal of Cancer Therapy, 2012, 3, 546-552 1 /10.4236/jct.2012.35070 Published Online October 2012 (http://www.SciRP.org/journal/jct) Combined 18F-FDG PET/CT with Enhanced CT Perform One-Stop Shop Imaging for Assessing Pancreatic Carcinoma * Miao Zhang, Min Zhang, Lihua Wang, Jiajia Hu, Biao Li Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. * Email: lb10363@, laurazm_cn@ Received August 8th, 2012; revised September 7th, 2012; accepted September 19th, 2012 ABSTRACT Objective: To evaluate the role of PET/CT with contrast enhanced CT in diagnosing and staging for pancreatic diseases and optimize the use of enhanced PET/CT as one-stop imaging modality. Methods: Fifty-six patients who presented with suspected pancreatic carcinoma underwent whole-body 18F-FDG PET/CT and enhanced CT imaging. Images were interpreted and compared with the histopathology findings. The sensitivity, specificity and accuracy of enhanced CT, PET/CT and combined PET/CT with contrast enhanced CT diagnosis were analyzed. The vascular invasion and distant metastases of pancreatic lesions on different imaging modality were analyzed and compared. Results: Among the fifty-six patients evaluated for primary tumor, thirty-nine patients had malignant diseases and seventeen had benign lesions. Sensitivity, specificity and accuracy of enhanced CT were 87.5%, 75% and 83.9%, those of non-enhanced PET/CT were 89.7%, 88.2% and 89.2%, of PET/CT with enhanced CT were 100%, 94.1% and 98.2%. Combined PET/CT with enhanced CT had highest sensitivity, specificity and accuracy in diagnosing pancreatic carcinoma. Aver- age SUVmax of m