complex tree the basic framework of protein-protein interaction networks复杂的树蛋白质相互作用网络的基本框架.pdfVIP

Vol.2, No.9, 998-1004 (2010) Natural Science /10.4236/ns.2010.29122 Complex tree: the basic framework of protein-protein interaction networks Dai-Chuan Ma1,2, Yuan-Bo Diao1,2, Yi-Zhou Li1,2, Yan-Zi Guo1,2, Jiang Wu1,2, Meng-Long Li1,2* 1College of Chemistry, Sichuan University, Chengdu, China; *Corresponding Author: liml@ 2State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China Received 22 May 2010; revised 26 July 2010; accepted 2 August 2010. ABSTRACT quantity of protein interaction data from several organ- isms such as yeast and fruit fly has been produced [2,3]. In living cells, proteins are dynamically connec- In the past decade, with the explosion of available hi- ted through biochemical reactions, so its functi- gh throughout biological data, the analysis of biological onal features are properly encoded into protein- networks has attracted significant interest in academic protein interaction networks (PINs). Up to pres- community. Since the “right-skewed” degree distribution ent, many efforts have been devoted to explor- of metabolic networks found by Jeong et al. [5], lots of ing the basic feature of PINs. However, it is still research works have been done to understand the biolo- a challenging problem to explore a universal pr- gical systems in terms of network. The system’s eleme- operty of PINs.