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considerations on blood platelets a neuron’s mirror for mood disorders考虑在血小板神经元对情绪障碍的镜子
Open Journal of Blood Diseases, 2012, 2, 22-29
/10.4236/ojbd.2012.22005 Published Online June 2012 (http://www.SciRP.org/journal/ojbd)
Considerations on Blood Platelets: A Neuron’s Mirror for
Mood Disorders?
1,2* 1 1
Massimo Cocchi , Lucio Tonello , Fabio Gabrielli
1Paolo Sotgiu Institute for Research in Quantitative Quantum Psychiatry Cardiology, LU de S University, Lugano, Switzerland;
2Department of Medical Veterinary Sciences, University of Bologna, Bologna, Italy.
*
Email: massimo.cocchi@unibo.it
Received March 7th, 2012; revised April 12th, 2012; accepted April 25th, 2012
ABSTRACT
This work aims to be a reflection concerning a remarkable similarity between platelet and neuron. Through a series of
experimental tests which have affected the fatty acid composition of the membrane of platelets, it was possible to pro-
vide a contribution to the scientific literature, which had already reported strong similarities between platelet and neuron.
The work performed could be of great interest to investigate, by studying the interactome of the platelet, the molecular
behavior of the neuron.
Keywords: Blood Platelets; Fatty Acids; Membrane Viscosity
1. Introduction Comparing platelet membrane fluidity in patients with
Alzheimer type dementia, the fluidity of the hydrocarbon
Platelets, which are considered cells with high affinity to
region of platelet membranes from the demented group,
neurons, have the same embryonic origin of brain and
as reflected by the steady-state anisotropy of the fluores-
skin (ectoderma) [1-4]. This affinity, primarily, is related
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