constitutively active soluble form of erythropoietin receptor suppresses growth and angiogenesis of xenografts of transfected cancer cell lines持续活跃的可溶性形式的红细胞生成素受体抑制生长和血管生成的异种移植癌症细胞系转染.pdfVIP

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constitutively active soluble form of erythropoietin receptor suppresses growth and angiogenesis of xenografts of transfected cancer cell lines持续活跃的可溶性形式的红细胞生成素受体抑制生长和血管生成的异种移植癌症细胞系转染.pdf

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constitutively active soluble form of erythropoietin receptor suppresses growth and angiogenesis of xenografts of transfected cancer cell lines持续活跃的可溶性形式的红细胞生成素受体抑制生长和血管生成的异种移植癌症细胞系转染

Journal of Cancer Therapy, 2011, 2, 40-53 doi:10.4236/jct.2011.21005 Published Online March 2011 (http://www.SciRP.org/journal/jct) Constitutively Active Soluble Form of Erythropoietin Receptor Suppresses Growth and Angiogenesis of Xenografts of Transfected Cancer Cell Lines –—Blockade of Epo in Xenografts of Cancer Cell Lines 1 2 3 4 1 1 Yoshiko Yasuda , Yasuhiro Maeda , Satoshi Hara , Motoyoshi Tanaka , Eiji Koike , Yoh Watanabe , 5 1 6 7 6 Seiji Masuda , Harufumi Yamasaki , Katsumi Okumoto , Hiroyoshi Konishi , Yoshitaka Horiuchi , Hiroshi Hoshiai1 1Department of Obstetrics and Gynecology, Kinki University School of Medicine, Osaka, Japan; 2Department of Hematology, Kinki University School of Medicine, Osaka, Japan; 3Department of Surgery, Kinki University School of Medicine, Osaka, Japan; 4Department of Urology, Kinki University School of Medicine, Osaka, Japan; 5Laboratory of Molecular Biology of Bioresponse, Graduate School of Biostudies, Kyoto University, Kyoto, Japan; 6Life Science Research Institute, Kinki University School of Medi- cine, Osaka, Japan; 7Faculty of Rehabilitation, Shijonawate Gakuen University, Osaka, Japan. Email: y1126yas@med.kindai.ac.jp Received December 21st, 2010; revised February 23rd, 2011; accepted March 2nd , 2011. ABSTRACT We examined the effect of blocking the erythropoietin (Epo) signaling using an anti-Epo antibody, soluble form of Epo receptor (sEpoR) capable of binding to Epo or EpoR antagonist, and proved to be effective against xenografts of female reproductive organ malignancies and of cancer cell lines in nude mice. We transfected seven cancer cell lines of vari- ous origins to