conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients with risk factors转换从钙调磷酸酶抑制剂西罗莫司维持治疗肾移植受者的危险因素.pdfVIP

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conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients with risk factors转换从钙调磷酸酶抑制剂西罗莫司维持治疗肾移植受者的危险因素.pdf

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conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients with risk factors转换从钙调磷酸酶抑制剂西罗莫司维持治疗肾移植受者的危险因素

Open Journal of Organ Transplant Surgery, 2011, 1, 8-13 doi:10.4236/ojots.2011.11002 Published Online August 2011 (http://www.SciRP.org/journal/ojots) Conversion from Calcineurin Inhibitors to Sirolimus Maintenance Therapy in Renal Allograft Recipients with Risk Factors 1 1 1 1 1 2* Shuming Ji , Jiqiu Wen , Dongrui Cheng , Qiquan Sun , Jinsong Chen , Zhihong Liu 1 Research Institute of Nephrology, Department of Nephropathy, Jinling Hospital, Nanjing, China 2Nanjing University School of Medicine, Nanjing, China * E-mail : jishuming@ Received July 31, 2011; revised August 17, 2011; accepted August 23, 2011 Abstract Background: The efficacy and safety of conversion treatment with sirolimus in renal transplant recipients using the calcineurin inhibitor (CNI) with one or more risk factors was evaluated. Methods: Ninety-three renal transplant recipients were prospectively enrolled. CNIs(CsA and FK506) as main immunosuppressant were converted to SRL immunosuppressant protocol. Rapid conversion with sirolimus was performed in all patients. The CNI withdrawal was in 2 weeks. At 4 hours after oral administration of cyclosporin A or tac- rolimus, the patients took sirolimus. Initial dose of sirolimus was 6 mg, and repeated maintenance dose is 1.0 - 2.0 mg/d. The first concentration of sirolimus was detected at 5 - 7 days after first oral administration, and the target concentration was 6 - 10 μg/L. Results: The symptoms were markedly improved in patients with CNI induced renal toxicity and CNI induced liver toxicity, and the concentration of sirolimus were main- tained at (5.1 ± 1.2