deoxyribonuclease is a potential counter regulator of aberrant neutrophil extracellular traps formation after major trauma脱氧核糖核酸酶是一个潜在的柜台后异常中性粒细胞胞外陷阱形成的监管机构重大创伤.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 149560, 8 pages doi:10.1155/2012/149560 Clinical Study Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma ¨ ¨ ¨ ´ ¨ ¨ Wei Meng, Adnana Paunel-Gorgulu, Sascha Flohe, Ingo Witte, Michael Schadel-Hopfner, ¨ Joachim Windolf, and Tim Tobias Logters Department of Trauma and Hand Surgery, University Hospital Dusseldorf, 40225 Dusseldorf, Germany ¨ ¨ ¨ Correspondence should be addressed to Adnana Paunel-Gorgulu, adnana.paunel-goeguelue@med.uni-duesseldorf.de Received 23 September 2011; Accepted 15 October 2011 Academic Editor: Frank Hildebrand Copyright © 2012 Wei Meng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Neutrophil extracellular traps (NET) consist of a DNA scaffold that can be destroyed by Deoxyribonuclease (DNase). Thus DNases are potential prerequisites for natural counter regulation of NETs formation. In the present study, we determined the relationship of NETs and DNase after major trauma. Methods. Thirty-nine major trauma patients, 14 with and 25 without sepsis development were enrolled in this prospective study. Levels of cell-free (cf)-DNA/NETs and DNase were quantified daily from admission until day 9 after admission. Results. Levels of cf-DNA/NETs in patients who developed sepsis were significantly