determinants of airway hyperresponsiveness—balance of tonic and phasic contractility of airway smooth muscles of lobular bronchioles决定因素的气道hyperresponsiveness-balance主音和相位的小叶细支气管的气道平滑肌的收缩性.pdfVIP

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determinants of airway hyperresponsiveness—balance of tonic and phasic contractility of airway smooth muscles of lobular bronchioles决定因素的气道hyperresponsiveness-balance主音和相位的小叶细支气管的气道平滑肌的收缩性.pdf

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determinants of airway hyperresponsiveness—balance of tonic and phasic contractility of airway smooth muscles of lobular bronchioles决定因素的气道hyperresponsiveness-balance主音和相位的小叶细支气管的气道平滑肌的收缩性

Open Journal of Molecular and Integrative Physiology, 2012, 2, 8-13 OJMIP /10.4236/ojmip.2012.21002 Published Online February 2012 (http://www.SciRP.org/journal/ojmip/) Determinants of airway hyperresponsiveness—Balance of tonic and phasic contractility of airway smooth muscles of lobular bronchioles Kyongyob Min, Keita Hosoi, Yoshinori Kinoshita, Satoshi Hara, Hiroyuki Degami, Tetsuo Takada, Takahiko Nakamura Respiratory Division, Department of Internal Medicine, Itami City Hospital, Hyogo, Japan Email: in1007@poh.osaka-med.ac.jp Received 17 September 2011; revised 13 November 2011; accepted 12 December 2011 ABSTRACT excessive airway narrowing, which was determined by the ratio of amplitudes between tonic and phasic Airway hyperresponsiveness (AHR) is a characteris- contractions, thus the balance of amplitudes between tic feature of asthma, and generally correlates with tonic and phasic contractions of peripheral lobular severity of asthma. Understanding the protection me- smooth muscles would be the determinant of AHR. chanism against excessive airway narrowing and how it breaks down is fundamental to solving the problem Keywords: Airway Hyperresponsiveness; Stochastic of asthma. In this paper we have proposed a stochas- Model of Airway Smooth Muscle; Ising-Type of tic modeling the airway smooth muscle bundle for Antimagetic Interactions; Percolation Process; Phasic reproducing AHR such as an increased sen