血清Tracp5b、CEA、CA15-3检测对乳腺癌骨转移临床意义.docVIP

血清Tracp5b、CEA、CA15-3检测对乳腺癌骨转移临床意义【摘要】 目的 探讨血清Tracp5b、CEA和CA15-3水平和乳腺癌骨转移的关系。方法 应用采用酶联免疫吸附试验（ELISA）和化学发光免疫分析（CLIA）检测78例乳腺癌术后患者血清Tracp5b、CEA、CA15-3水平，其中骨转移39例，无骨转移39例（含骨外转移9例）以及健康女性对照组30例。结果 骨转移组血清TRACP5b水平为（6.25±2.37），显著高于健康对照组（3.29±1.15）、无骨转移组（3.99±1.02）以及骨外转移组（4.08±1.10）（?P?0.05）；骨转移组血清CA15-3水平为（148.3±173.5），显著高于健康对照组（13.88±7.12）和无骨转移组（15.21±7.62）（?P?0.05）；骨转移组CEA水平为（19.8±10.20），显著高于健康对照组（2.69±1.10）和无骨转移组（3.19±1.32）（?P?0.05）。结论 血清TRACP5b的检测对乳腺癌骨转移具有较高的特异性和敏感性，而?CA15-?3、CEA在乳腺癌骨转移时具有较高的相关性，但不具备特异性。? 【关键词】 乳腺癌； 骨转移； 抗酒石酸酸性磷酸酶5b； CA15-3； CEA?? Serum Tracp5b, CEA, CA15-3 to breast cancer detection of bone metastases clinical significance ?ZHOU Jin-hong, LIU Zhen-zong. Nantong university hospital, Jiangsu 226001, China?? 【Abstract】 Objective Explore Tracp5b serum, CEA and CA15-3 level and breast cancer bone metastasis of the relationship.Methods Application by ELISA test(ELISA) and chemical luminescence immune cent fold(CLIA) testing 78 cases of breast cancer patients with postoperative serum Tracp5b, CEA, CA15-3 level, including bone 39 cases, no bone 39 cases(including bone transfer 9 cases) and healthy women 30 patients in the control group.Results Bone in serum TRACP5b 6.25 level of +/- 2.37, significantly higher than that in the control group health(3.29 +/- 1.15), no bone group(3.99 +/- 1.02) and bone transfer group(4.08 +/- 1.10)(?P?0.05). Bone group CA15-3 level of serum different significantly higher than that in the control group health(13.88 +/- 7.12) and no bone group(15.21 +/- 7.62)(?P?0.05). Bone group the 19.8 level CEA +/- 10.20, significantly higher than that in the control group health(2.69 +/- 1.10) and no bone group(3.19 +/- 1.32)(?P?0.05).Conclusion Serum TRACP5b test for breast cancer has spread to the bone high specificity and sensitivity, and CA15-3, CEA in breast cancer bone metastasis has high correlation, but do not have specific.? 【Key words】 CA15-3; CEA; Breast cancer; Bone metastasis; Tartaric acid resistance of acidic phosphata