偏头痛患者发作间期磁共振脑局部一致性研究.docVIP

偏头痛患者发作间期磁共振脑局部一致性研究 禹智波1,3 彭婧2 黎海涛1* 周振华2 谢兵1 （1.第三军医大学西南医院放射科，2.第三军医大学西南医院神内科，重庆 400038； 3.解放军第324医院医学影像科，重庆 400020） [摘要] 目的 采用局部一致性分析方法分析偏头痛患者的静息态功能磁共振成像影像，探讨偏头痛患者静息状态下自发神经活动特点及脑功能变化。方法 随机A Study of Patients with Migraine during Interictal Period Using Regional Homogeneity YU Zhi-bo1,3，PENG Jing2，LI Hai-tao1*，ZHOU Zhen-hua2，XIE Bing1 （1.Department of Radiology，2. Department of Neurology，Southwest Hospital，Third Military Medical University，Chongqing 400038，China；3. Department of Medical Imaging，PLA No.324 Hospital，Chongqing 400020，China） [Abstract] Objective To examine spontaneous neuronal activity (SNA) and brain function alteration of patients with migraine during interictal period with resting state functional magnetic resonance imaging ( rs-fMRI) and regional homogeneity ( ReHo ) analysis. Methods Twenty patients with migraine during interictal period and nineteen healthy controls, matched for age, sex and education, were enrolled and scanned with rs-fMRI. The rs-fMRI data were preprocessed and calculated to obtain whole brain ReHo values with DPARSF software. The raw ReHo values were subjected to t-test of two independent samples with SPM8 software. Results Compared with controls, patients with migraine during interictal period had abnormal SNA in several brain regions related to cognitive control and emotional processing, including the frontal lobe, temporal lobe and parietal lobe, etc. ReHo increase was observed in the bilateral anterior cingulate cortex, bilateral rectus gyrus, right precuneus, right posterior cingulate cortex, right inferior parietal lobule, right middle temporal gyrus, right superior temporal gyrus (P 0.01), and ReHo decrease was observed in the bilateral supplementary motor area, double side paracentral lobule, right medial frontal gyrus, left dorsal anterior cingulate cortex, left limbic lobe (P 0.01). Conclusion Abnormal resting-state functional connectivity exists in several interactions between brain regions of the brain netwo