a pilot study of ketamine versus midazolamfentanyl sedation in children undergoing gi endoscopy的试点研究氯胺酮对midazolamfentanyl镇静儿童接受胃肠道内窥镜检查.pdfVIP

Hindawi Publishing Corporation International Journal of Pediatrics Volume 2011, Article ID 623710, 6 pages doi:10.1155/2011/623710 Clinical Study A Pilot Study of Ketamine versus Midazolam/Fentanyl Sedation in Children Undergoing GI Endoscopy Jenifer R. Lightdale,1 Paul D. Mitchell,2 Meghan E. Fredette,3 Lisa B. Mahoney,4 Steven E. Zgleszewski,2 Lisa Scharff,2 and Victor L. Fox1 1 Division of Gastroenterology, Children’s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA 2 Children’s Hospital Boston, Boston, MA 02115, USA 3 University of Connecticut School of Medicine, Farmington, CT 06030, USA 4 Boston University School of Medicine, Boston, MA 02118, USA Correspondence should be addressed to Jenifer R. Lightdale, jenifer.lightdale@ Received 16 November 2010; Revised 21 February 2011; Accepted 3 March 2011 Academic Editor: Mark A. Gilger Copyright © 2011 Jenifer R. Lightdale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Ketamine sedation has been found superior by physician report to traditional sedation regimens for pediatric endoscopy. Goal. To objectively compare sedation with ketamine versus midazolam/fentanyl for children undergoing gastrointestinal endoscopy. Study. Patients received one of two regimens and were independently monitored using a standardized rating scale. Results. There were 2 episodes of laryngospasm during ketamine sedation. Univariate analyses showed patients sedated with ketamine (n = 17) moved more (median 25% of procedure time versus 8%, P = .03) and required similar low le