原创力文档a pilot study for the neuroprotective effect of gongjin-dan on transient middle cerebral artery occlusion-induced ischemic rat brain神经保护作用的初步研究短暂性大脑中动脉gongjin-dan occlusion-induced缺血性老鼠大脑.pdfVIP
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a pilot study for the neuroprotective effect of gongjin-dan on transient middle cerebral artery occlusion-induced ischemic rat brain神经保护作用的初步研究短暂性大脑中动脉gongjin-dan occlusion-induced缺血性老鼠大脑
Hindawi Publishing Corporation
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 682720, 11 pages
doi:10.1155/2012/682720
Research Article
A Pilot Study for the Neuroprotective Effect of
Gongjin-dan on Transient Middle Cerebral Artery
Occlusion-Induced Ischemic Rat Brain
Yun-Young Sunwoo,1 Sang In Park,1 Yong-An Chung,1, 2 Jisoo Lee,3 Moon-Seo Park,1
Kyung-Sool Jang,1 Lee-So Maeng,1 Dong-Kyu Jang,1 Ruth Im,1 Yu Jin Jung,1 Soon A. Park,1
Eun-Sun Kang,1 Min-Wook Kim,1 and Young-Min Han1
1 Institute of Catholic Integrative Medicine (ICIM), Incheon St. Mary’s Hospital, The Catholic University of Korea,
Incheon 403-720, Republic of Korea
2 Department of Radiology, Incheon St. Mary’s Hospital, The Catholic University of Korea, Incheon 403-720, Republic of Korea
3 Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
Correspondence should be addressed to Yong-An Chung, nm@catholic.ac.kr
Received 30 January 2012; Revised 30 March 2012; Accepted 31 March 2012
Academic Editor: Ilkay Erdogan Orhan
Copyright © 2012 Yun-Young Sunwoo et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
In this study, we investigated whether gongjin-dan improves functional recovery and has neuroprotective effects on reducing
the infarct volume after transient middle cerebral artery occlusion (MCAo). Infarct volume was measured using TTC staining
and glucose utilization by F-18 FDG PET. Functional improvement was evaluated with the Rota-rod, treadmill, Garcia score
test, and adhesive removal test. At 14 days after MCAo, neuronal cell survival, a
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