a standardized extract of ginkgo biloba neutralizes cisplatin-mediated reproductive toxicity in rats标准化的提取银杏叶中和cisplatin-mediated大鼠的生殖毒性.pdfVIP

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a standardized extract of ginkgo biloba neutralizes cisplatin-mediated reproductive toxicity in rats标准化的提取银杏叶中和cisplatin-mediated大鼠的生殖毒性.pdf

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a standardized extract of ginkgo biloba neutralizes cisplatin-mediated reproductive toxicity in rats标准化的提取银杏叶中和cisplatin-mediated大鼠的生殖毒性

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 362049, 11 pages doi:10.1155/2012/362049 Research Article A Standardized Extract of Ginkgo biloba Neutralizes Cisplatin-Mediated Reproductive Toxicity in Rats Amr Amin,1, 2 Christeena Abraham,1 Alaaeldin A. Hamza,1 Zeinab A. Abdalla,1 Shaikha B. Al-Shamsi,1 Saina S. Harethi,1 and Sayel Daoud3 1 Biology Department, United Arab Emirates University, Al Ain 17551, UAE 2 Zoology Department, Cairo University, Giza, Egypt 3 Histopathology Laboratory, Tawam Hospital in aﬃ liation with Johns Hopkins Medicine, Al Ain, UAE Correspondence should be addressed to Amr Amin, a.amin@uaeu.ac.ae Received 26 January 2012; Revised 15 February 2012; Accepted 27 February 2012 ˇ Academic Editor: Metka Filipic Copyright © 2012 Amr Amin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The aim of this study was to evaluate the protective eﬀects of Ginkgo biloba (GB) against testicular damage and oxidative stress as well as caudal sperm indices in a cisplatin- (CIS-) induced rodent model. Adult male Wistar rats were given vehicle, single i.p. dose of CIS alone (10 mg/kg), GB alone (200 mg g/kg every day for ﬁve days), or single dose of CIS followed by GB (50, 100, or 200 mg/kg every day for ﬁve days). On day 6, after the ﬁrst drug treatment oxidative and apoptotic testicular toxicity was evaluated. CIS-treated rats displayed decreased weights of testes and epididymis as well as caudal sperm count and motility. This reproductive toxicity was accompanied with increased germ-cell degeneration