a versatile polymer micelle drug delivery system for encapsulation and in vivo stabilization of hydrophobic anticancer drugs一种多功能聚合物胶束药物输送系统封装和疏水性抗癌药物的体内稳定.pdfVIP

Hindawi Publishing Corporation Journal of Drug Delivery Volume 2012, Article ID 951741, 8 pages doi:10.1155/2012/951741 Research Article A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs Jonathan Rios-Doria,1 Adam Carie,1 Tara Costich,1 Brian Burke,1 Habib Skaff,1 Riccardo Panicucci,2 and Kevin Sill1 1 Intezyne Inc., 3720 Spectrum Boulevard, Suite 104, Tampa, FL 33612, USA 2 Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA Correspondence should be addressed to Kevin Sill, kevin.sill@ Received 27 July 2011; Accepted 15 October 2011 Academic Editor: Eliana B. Souto Copyright © 2012 Jonathan Rios-Doria et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Chemotherapeutic drugs are widely used for the treatment of cancer; however, use of these drugs is often associated with patient toxicity and poor tumor delivery. Micellar drug carriers offer a promising approach for formulating and achieving improved delivery of hydrophobic chemotherapeutic drugs; however, conventional micelles do not have long-term stability in complex biological environments such as plasma. To address this problem, a novel triblock copolymer has been developed to encapsulate several different hydrophobic drugs into stable polymer micelles. These micelles have been engineered to be stable at low concentrations even in complex biological fluids, and to release cargo in response to low pH environments, such as in the tumor microenvironment or in tumor cell endosomes. The particle sizes of drugs encapsul